Reproductive Outcome of Women with 21-Hydroxylase-Deficient Nonclassic Adrenal Hyperplasia
نویسندگان
چکیده
منابع مشابه
Treatment and Outcome of Congenital Adrenal Hyperplasia: 21-Hydroxylase Deficiency
The use of glucocorticoids to treat individuals with congenital adrenal hyperplasia (CAH) was first reported by both Wilkins and Bartter in 1950. Since that time, the care of these patients has improved dramatically, and through the efforts of dedicated medical researchers, it continues to improve today. With early detection by newborn screening, initiation of treatment in infants with salt-was...
متن کاملnon classic 21 hydroxylase deficient adrenal hyperplasia in patients with isolated precocious pubarche
precocious pubarche (pp) is most often a benign condition secondary to the early appearance of adrenarche. however, pp may be a manifestation of mild errors of steroidogenesis in particular non classic 21 hydroxylase deficiency (nc210hd). the incidence of nc210hd in patients with pp ranges from about 0-30% of cases in various reports. controversy exists as to whether all children with pp should...
متن کاملFertility and pregnancy outcome in women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
BACKGROUND Low pregnancy rate has been reported in women with congenital adrenal hyperplasia (CAH) and little information on pregnancy and children is known. METHODS In a Swedish study, 62 adult women with CAH, aged 18-63 years, and 62 age-matched controls were followed-up. Medical records, including those concerning pregnancies and deliveries, were examined and the 21-hydroxylase genotype of...
متن کاملNonclassic Congenital Adrenal Hyperplasia
PURPOSE OF REVIEW Late-onset or nonclassic congenital adrenal hyperplasia (NCAH) due to 21-hydroxylase deficiency is one of the most common autosomal recessive disorders. Reported prevalence ranges from 1 in 30 to 1 in 1000. Affected individuals typically present due to signs and symptoms of androgen excess. The purpose of this review is to provide current information regarding the pathophysiol...
متن کاملLong-Term Gynecological Outcomes in Women with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency
Background. Our knowledge on long-term outcome in CAH remains incomplete. Methods. In a prospective study (33 CAH patients, 33 age-matched controls), reproductive outcomes, self-rating of genital appearance and function, and sexuality were correlated to degree of initial virilisation, genotype, and surgery. Results. Patients had larger median clitoral lengths (10.0 mm [range 2-30] versus 3.5 [2...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2006
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2006-0062